Drug Name Levlen

Biotransformation of these drugs involves cytochrome P450 (CYP 3A4) and is therefore subject to interaction with various other drugs inactivated via this route.
The most important adverse effects are due to hypersensitivity (incidence up to 5%), with manifestations ranging from skin eruptions to anaphylactic shock (in less than 0. 05% of patients). Known penicillin allergy is a contraindication for these drugs. Because of an increased risk of sensitization, penicillins must not be used locally.

 

The feasibility of this route is determined by both the physicochemical properties of the drug and the therapeutic requirements (acute vs.long-term effect). Speed of absorption is determined by the route and method of application. It is fastest with intravenous injection, less fast which intramuscular injection, and slowest with subcutaneous injection.
Clopidogrel reportedly does not cause hematological problems. As peptides, hirudin and abciximab need to be injected; therefore their use is restricted to intensive-care settings. Major blood loss entails the danger of life-threatening circulatory failure, i. e. , hypovolemic shock.